CATH Domain 4f95A00

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.90	Alpha-Beta Complex
	3.90.950	Maf protein
	3.90.950.10

Domain Context

CATH Clusters

Superfamily	3.90.950.10
Functional Family	Inosine triphosphate pyrophosphatase

Enzyme Information

3.6.1.9

Nucleotide diphosphatase.

based on mapping to UniProt Q9BY32

A nucleoside triphosphate + H(2)O = a nucleotide + diphosphate.

-!- The enzyme preferentially hydrolyzes ATP, but can also hydrolyze other nucleoside 5' triphosphates such as GTP, CTP, TTP and UTP to their corresponding monophosphates. -!- In vitro the enzyme also acts as a nucleotidohydrolase on ADP, NAD(+), NADP(+), FAD, and CoA. -!- Formerly EC 3.6.1.19.

UniProtKB Entries (1)

Q9BY32

ITPA_HUMAN

Homo sapiens

Inosine triphosphate pyrophosphatase

PDB Structure

PDB	4F95
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	The human ITPA polymorphic variant P32T is destabilized by the unpacking of the hydrophobic core. Simone, P.D., Struble, L.R., Kellezi, A., Brown, C.A., Grabow, C.E., Khutsishvili, I., Marky, L.A., Pavlov, Y.I., Borgstahl, G.E. J.Struct.Biol.