1 keywords

CATH Domain 4f6xA00

CATH Classification

Level CATH Code Description
Class 1 Mainly Alpha
Architecture 1.10 Orthogonal Bundle
Topology 1.10.600 Farnesyl Diphosphate Synthase
Homologous Superfamily 1.10.600.10 Farnesyl Diphosphate Synthase

Domain Context

CATH Clusters

Superfamily Farnesyl Diphosphate Synthase
Functional Family Dehydrosqualene synthase

Enzyme Information

2.5.1.96
4,4'-diapophytoene synthase.
based on mapping to UniProt A9JQL9
2 (2E,6E)-farnesyl diphosphate = 15-cis-4,4'-diapophytoene + 2 diphosphate.
-!- Typical of Staphylococcus aureus and some other bacteria such as Heliobacillus sp.

UniProtKB Entries (1)

A9JQL9
CRTM_STAAU
Staphylococcus aureus
4,4'-diapophytoene synthase

PDB Structure

PDB 4F6X
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
HIV-1 Integrase Inhibitor-Inspired Antibacterials Targeting Isoprenoid Biosynthesis.
Zhang, Y., Lin, F.-Y., Li, K., Zhu, W., Liu, Y.L., Cao, R., Pang, R., Lee, E., Axelson, J., Hensler, M., Wang, K., Molohon, K.J., Wang, Y., Mitchell, D.A., Nizet, V., Oldfield, E.
ACS Med Chem Lett