CATH Domain 4f5cA02

CATH Classification

Level	CATH Code	Description
	1	Mainly Alpha
	1.10	Orthogonal Bundle
	1.10.390	Neutral Protease; domain 2
	1.10.390.10	Neutral Protease Domain 2

Domain Context

CATH Clusters

Superfamily	Neutral Protease Domain 2
Functional Family

Enzyme Information

3.4.11.2

Membrane alanyl aminopeptidase.

based on mapping to UniProt P15145

Release of an N-terminal amino acid, Xaa-|-Yaa- from a peptide, amide or arylamide. Xaa is preferably Ala, but may be most amino acids including Pro (slow action). When a terminal hydrophobic residue is followed by a prolyl residue, the two may be released as an intact Xaa-Pro dipeptide.

-!- Is not activated by heavy metal ions. -!- Belongs to peptidase family M1. -!- Formerly EC 3.4.1.2, EC 3.4.3.5 and EC 3.4.13.6.

UniProtKB Entries (2)

P15145	AMPN_PIG Sus scrofa Aminopeptidase N
Q84852	Q84852_9ALPC Porcine respiratory coronavirus S protein

PDB Structure

PDB	4F5C
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Structural bases of coronavirus attachment to host aminopeptidase N and its inhibition by neutralizing antibodies. Reguera, J., Santiago, C., Mudgal, G., Ordono, D., Enjuanes, L., Casasnovas, J.M. Plos Pathog.