CATH Classification

Domain Context

CATH Clusters

Superfamily 3.40.630.30
Functional Family Acetyltransf_1

Enzyme Information

2.3.1.82
Aminoglycoside 6'-N-acetyltransferase.
based on mapping to UniProt Q44057
Acetyl-CoA + kanamycin-B = CoA + N(6')-acetylkanamycin-B.
-!- The antibiotics kanamycin A, kanamycin B, neomycin, gentamicin C(1a), gentamicin C(2), sisomicin and tobramycin are substrates. -!- The antibiotic paromomycin is not a substrate. -!- The 6-amino group of the purpurosamine ring is acetylated. -!- Formerly EC 2.3.1.55.

UniProtKB Entries (1)

Q44057
AAC6_ACIHA
Acinetobacter haemolyticus
Aminoglycoside N(6')-acetyltransferase type 1

PDB Structure

PDB 4F0Y
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structural and Biochemical Characterization of Acinetobacter spp. Aminoglycoside Acetyltransferases Highlights Functional and Evolutionary Variation among Antibiotic Resistance Enzymes.
Stogios, P.J., Kuhn, M.L., Evdokimova, E., Law, M., Courvalin, P., Savchenko, A.
ACS Infect Dis.