CATH Classification

Domain Context

CATH Clusters

Superfamily 3.40.50.10090
Functional Family Uroporphyrinogen-III synthase

Enzyme Information

4.2.1.75
Uroporphyrinogen-III synthase.
based on mapping to UniProt P48246
Hydroxymethylbilane = uroporphyrinogen III + H(2)O.
-!- In the presence of EC 2.5.1.61, forms uroporphyrinogen III from porphobilinogen.

UniProtKB Entries (1)

P48246
HEM4_PSEAE
Pseudomonas aeruginosa PAO1
Uroporphyrinogen-III synthase

PDB Structure

PDB 4ES6
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
The AEROPATH project targeting Pseudomonas aeruginosa: crystallographic studies for assessment of potential targets in early-stage drug discovery.
Moynie, L., Schnell, R., McMahon, S.A., Sandalova, T., Boulkerou, W.A., Schmidberger, J.W., Alphey, M., Cukier, C., Duthie, F., Kopec, J., Liu, H., Jacewicz, A., Hunter, W.N., Naismith, J.H., Schneider, G.
Acta Crystallogr.,Sect.F