CATH Classification

Domain Context

CATH Clusters

Superfamily FAD/NAD(P)-binding domain
Functional Family

Enzyme Information

1.8.1.14
CoA-disulfide reductase.
based on mapping to UniProt Q2FIA5
2 CoA + NADP(+) = CoA-disulfide + NADPH.
-!- Not identical with EC 1.8.1.6, EC 1.8.1.7 or EC 1.8.1.13. -!- The enzyme from the bacterium Staphylococcus aureus has a strong preference for NADPH, while the bacterium Bacillus megaterium contains both NADH and NADPH-dependent enzymes. -!- Formerly EC 1.6.4.10.

UniProtKB Entries (1)

Q2FIA5
CDR_STAA3
Staphylococcus aureus subsp. aureus USA300
Coenzyme A disulfide reductase

PDB Structure

PDB 4EQW
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Turnover-Dependent Covalent Inactivation of Staphylococcus aureus Coenzyme A-Disulfide Reductase by Coenzyme A-Mimetics: Mechanistic and Structural Insights.
Wallace, B.D., Edwards, J.S., Wallen, J.R., Moolman, W.J., van der Westhuyzen, R., Strauss, E., Redinbo, M.R., Claiborne, A.
Biochemistry
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