CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.50 | 3-Layer(bba) Sandwich |
|
3.50.50 | FAD/NAD(P)-binding domain |
|
3.50.50.60 | FAD/NAD(P)-binding domain |
Domain Context
CATH Clusters
| Superfamily | FAD/NAD(P)-binding domain |
| Functional Family |
Enzyme Information
| 1.8.1.14 |
CoA-disulfide reductase.
based on mapping to UniProt Q2FIA5
2 CoA + NADP(+) = CoA-disulfide + NADPH.
-!- Not identical with EC 1.8.1.6, EC 1.8.1.7 or EC 1.8.1.13. -!- The enzyme from the bacterium Staphylococcus aureus has a strong preference for NADPH, while the bacterium Bacillus megaterium contains both NADH and NADPH-dependent enzymes. -!- Formerly EC 1.6.4.10.
|
UniProtKB Entries (1)
| Q2FIA5 |
CDR_STAA3
Staphylococcus aureus subsp. aureus USA300
Coenzyme A disulfide reductase
|
PDB Structure
| PDB | 4EMW |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Turnover-Dependent Covalent Inactivation of Staphylococcus aureus Coenzyme A-Disulfide Reductase by Coenzyme A-Mimetics: Mechanistic and Structural Insights.
Biochemistry
|
