CATH Domain 4emmA00

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.90	Alpha-Beta Complex
	3.90.226	2-enoyl-CoA Hydratase; Chain A, domain 1
	3.90.226.10	2-enoyl-CoA Hydratase; Chain A, domain 1

Domain Context

CATH Clusters

Superfamily	2-enoyl-CoA Hydratase; Chain A, domain 1
Functional Family	ATP-dependent Clp protease proteolytic subunit

Enzyme Information

3.4.21.92

Endopeptidase Clp.

based on mapping to UniProt P63786

Hydrolysis of proteins to small peptides in the presence of ATP and magnesium. Alpha-casein is the usual test substrate. In the absence of ATP, only oligopeptides shorter than five residues are hydrolyzed (such as succinyl-Leu-Tyr-|-NHMec, and Leu-Tyr-Leu-|-Tyr-Trp, in which cleavage of the -Tyr-|-Leu- and -Tyr-|-Trp bonds also occurs).

-!- Belongs to peptidase family S14.

UniProtKB Entries (1)

P63786

CLPP_STAAW

Staphylococcus aureus subsp. aureus MW2

ATP-dependent Clp protease proteolytic subunit

PDB Structure

PDB	4EMM
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Helix unfolding/refolding characterizes the functional dynamics of Staphylococcus aureus Clp protease Ye, F., Zhang, J., Liu, H., Hilgenfeld, R., Zhang, R., Kong, X., Li, L., Lu, J., Zhang, X., Li, D., Jiang, H., Yang, C.-G., Luo, C. J.Biol.Chem.