CATH Domain 4dylA01

CATH Classification

Level	CATH Code	Description
	1	Mainly Alpha
	1.20	Up-down Bundle
	1.20.1270	Substrate Binding Domain Of Dnak; Chain:A; Domain 2
	1.20.1270.60	Arfaptin homology (AH) domain/BAR domain

Domain Context

CATH Clusters

Superfamily	Arfaptin homology (AH) domain/BAR domain
Functional Family	Tyrosine-protein kinase

Enzyme Information

2.7.10.2

Non-specific protein-tyrosine kinase.

based on mapping to UniProt P07332

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.

-!- Unlike EC 2.7.10.1, this protein-tyrosine kinase does not have a transmembrane domain. -!- In the human genome, 32 non-specific protein-tyrosine kinases have been identified and these can be divided into 10 families. -!- Formerly EC 2.7.1.112.

UniProtKB Entries (1)

P07332

FES_HUMAN

Homo sapiens

Tyrosine-protein kinase Fes/Fps

PDB Structure

PDB	4DYL
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	F-BAR domain of human FES tyrosine kinase Ugochukwu, E., Salah, E., Elkins, J., Barr, A., Krojer, T., Filippakopoulos, P., Weigelt, J., Arrowsmith, C.H., Edwards, A., Bountra, C., von Delft, F., Knapp, S., Structural Genomics Consortium (SGC) TO BE PUBLISHED