1 keywords

CATH Domain 4durB01

CATH Classification

Level CATH Code Description
Class 3 Alpha Beta
Architecture 3.50 3-Layer(bba) Sandwich
Topology 3.50.4 Hepatocyte Growth Factor
Homologous Superfamily 3.50.4.10 Hepatocyte Growth Factor

Domain Context

CATH Clusters

Superfamily Hepatocyte Growth Factor
Functional Family Plasminogen

Enzyme Information

3.4.21.7
Plasmin.
based on mapping to UniProt P00747
Preferential cleavage: Lys-|-Xaa > Arg-|-Xaa, higher selectivity than trypsin. Converts fibrin into soluble products.
-!- Formed from plasminogen by proteolysis which results in multiple forms of the active plasmin. -!- Belongs to peptidase family S1. -!- Formerly EC 3.4.4.14.

UniProtKB Entries (1)

P00747
PLMN_HUMAN
Homo sapiens
Plasminogen

PDB Structure

PDB 4DUR
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
The X-ray crystal structure of full-length human plasminogen
Law, R.H.P., Caradoc-Davies, T., Cowieson, N., Horvath, A.J., Quek, A.J., Encarnacao, J.A., Steer, D., Cowan, A., Zhang, Q., Lu, B.G.C., Pike, R.N., Smith, A.I., Coughlin, P.B., Whisstock, J.C.
Cell Rep