CATH Domain 4ddrA00

Level	CATH Code	Description
	3	Alpha Beta
	3.40	3-Layer(aba) Sandwich
	3.40.430	Dihydrofolate Reductase, subunit A
	3.40.430.10	Dihydrofolate Reductase, subunit A

Superfamily	Dihydrofolate Reductase, subunit A
Functional Family

1.5.1.3

Dihydrofolate reductase.

based on mapping to UniProt P00374

5,6,7,8-tetrahydrofolate + NADP(+) = 7,8-dihydrofolate + NADPH.

-!- The enzyme from animals and some micro-organisms also slowly reduces folate to 5,6,7,8-tetrahydrofolate. -!- Formerly EC 1.5.1.4.

DYR_HUMAN

Homo sapiens

Dihydrofolate reductase

PDB	4DDR
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Malarial dihydrofolate reductase as a paradigm for drug development against a resistance-compromised target Yuthavong, Y., Tarnchompoo, B., Vilaivan, T., Chitnumsub, P., Kamchonwongpaisan, S., Charman, S.A., McLennan, D.N., White, K.L., Vivas, L., Bongard, E., Thongphanchang, C., Taweechai, S., Vanichtanankul, J., Rattanajak, R., Arwon, U., Fantauzzi, P., Yuvaniyama, J., Charman, W.N., Matthews, D. Proc.Natl.Acad.Sci.USA