CATH Domain 4d2sA01

Level	CATH Code	Description
	3	Alpha Beta
	3.30	2-Layer Sandwich
	3.30.200	Phosphorylase Kinase; domain 1
	3.30.200.20	Phosphorylase Kinase; domain 1

Superfamily	Phosphorylase Kinase; domain 1
Functional Family	Dual specificity protein kinase TTK

2.7.12.1

Dual-specificity kinase.

based on mapping to UniProt P33981

ATP + a protein = ADP + a phosphoprotein.

-!- This family of enzymes can phosphorylate both Ser/Thr and Tyr residues. -!- Formerly EC 2.7.1.37.

TTK_HUMAN

Homo sapiens

Dual specificity protein kinase TTK

PDB	4D2S
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Discovery and Optimization of a Novel Series of Dyrk1B Kinase Inhibitors to Explore a Mek Resistance Hypothesis. Kettle, J.G., Ballard, P., Bardelle, C., Cockerill, M., Colclough, N., Critchlow, S.E., Debreczeni, J.E., Fairley, G., Fillery, S., Graham, M.A., Goodwin, L., Guichard, S., Hudson, K., Ward, R.A., Whittaker, D. J.Med.Chem.