CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.40 | 3-Layer(aba) Sandwich |
|
3.40.1180 | Undecaprenyl pyrophosphate synthetase |
|
3.40.1180.10 | Decaprenyl diphosphate synthase-like |
Domain Context
CATH Clusters
| Superfamily | Decaprenyl diphosphate synthase-like |
| Functional Family | Diterpene synthase |
Enzyme Information
| 3.1.7.8 |
Tuberculosinol synthase.
based on mapping to UniProt P9WJ61
Tuberculosinyl diphosphate + H(2)O = tuberculosinol + diphosphate.
-!- Only found in species of Mycobacterium that cause tuberculosis. -!- In addition, it also gives isotuberculosinol in 1:1 mixture, cf. EC 3.1.7.9.
|
| 3.1.7.9 |
Isotuberculosinol synthase.
based on mapping to UniProt P9WJ61
Tuberculosinyl diphosphate + H(2)O = (13S)-isotuberculosinol + diphosphate.
-!- Only found in species of Mycobacterium that cause tuberculosis. -!- In addition, it also gives tuberculosinol in 1:1 mixture, cf EC 3.1.7.8. -!- The isotuberculosinol form was a 3:1 mixture of the 13S and 13R forms, respectively.
|
UniProtKB Entries (1)
| P9WJ61 |
TUBOL_MYCTU
Mycobacterium tuberculosis H37Rv
Diterpene synthase
|
PDB Structure
| PDB | 4CMW |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Molecular Profiling of Mycobacterium Tuberculosis Identifies Tuberculosinyl Nucleoside Products of the Virulence-Associated Enzyme Rv3378C.
Proc.Natl.Acad.Sci.USA
|