CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
2 | Mainly Beta |
|
2.70 | Distorted Sandwich |
|
2.70.20 | Topoisomerase I; domain 3 |
|
2.70.20.10 | Topoisomerase I, domain 3 |
Domain Context
CATH Clusters
| Superfamily | Topoisomerase I, domain 3 |
| Functional Family | DNA topoisomerase |
Enzyme Information
| 5.6.2.2 |
DNA topoisomerase.
based on mapping to UniProt Q13472
ATP-independent breakage of single-stranded DNA, followed by passage and rejoining.
-!- These enzymes bring about the conversion of one topological isomer of DNA into another, e.g., the relaxation of superhelical turns in DNA, the interconversion of simple and knotted rings of single-stranded DNA, and the intertwisting of single-stranded rings of complementary sequences, cf. EC 5.6.2.3. -!- Formerly EC 5.99.1.2.
|
UniProtKB Entries (1)
| Q13472 |
TOP3A_HUMAN
Homo sapiens
DNA topoisomerase 3-alpha
|
PDB Structure
| PDB | 4CHT |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Structural and Mechanistic Insight Into Holliday-Junction Dissolution by Topoisomerase Iiialpha and Rmi1
Nat.Struct.Mol.Biol.
|