CATH Domain 4cfsA01

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.40	3-Layer(aba) Sandwich
	3.40.50	Rossmann fold
	3.40.50.1820	alpha/beta hydrolase

Domain Context

CATH Clusters

Superfamily	alpha/beta hydrolase
Functional Family

Enzyme Information

1.13.11.48

3-hydroxy-2-methylquinolin-4-one 2,4-dioxygenase.

based on mapping to UniProt O31266

3-hydroxy-2-methyl-1H-quinolin-4-one + O(2) = N-acetylanthranilate + CO.

-!- Does not contain a metal center or organic cofactor. -!- Fission of two C-C bonds: 2,4-dioxygenolytic cleavage with concomitant release of carbon monoxide. -!- The enzyme from Arthrobacter sp. can also act on 3-hydroxy-4- oxoquinoline, forming N-formylanthranilate and CO (cf. EC 1.13.11.47), but more slowly.

UniProtKB Entries (1)

O31266

HOD_PAENT

Paenarthrobacter nitroguajacolicus

1H-3-hydroxy-4-oxoquinaldine 2,4-dioxygenase

PDB Structure

PDB	4CFS
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Origin of the Proton-Transfer Step in the Cofactor-Free 1-H-3-Hydroxy-4-Oxoquinaldine 2,4- Dioxygenase: Effect of the Basicity of an Active Site His Residue. Hernandez-Ortega, A., Quesne, M.G., Bui, S., Heuts, D.P., Steiner, R.A., Heyes, D.J., De Visser, S.P., Scrutton, N.S. J.Biol.Chem.