CATH Domain 4cdgA04

CATH Classification

Level	CATH Code	Description
	1	Mainly Alpha
	1.10	Orthogonal Bundle
	1.10.150	DNA polymerase; domain 1
	1.10.150.80	HRDC domain

Domain Context

CATH Clusters

Superfamily	HRDC domain
Functional Family	Bloom syndrome RecQ-like helicase

Enzyme Information

3.6.4.12

DNA helicase.

based on mapping to UniProt P54132

ATP + H(2)O = ADP + phosphate.

-!- DNA helicases utilize the energy from ATP hydrolysis to unwind double-stranded DNA. -!- Some of them unwind duplex DNA with a 3' to 5' polarity (1,3,5,8), other show 5' to 3' polarity (10,11,12,13) or unwind DNA in both directions (14,15). -!- Some helicases unwind DNA as well as RNA (4,9). -!- May be identical with EC 3.6.4.13 (RNA helicase).

UniProtKB Entries (1)

P54132

BLM_HUMAN

Homo sapiens

Bloom syndrome protein

PDB Structure

PDB	4CDG
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Crystal Structure of the Bloom'S Syndrome Helicase Indicates a Role for the Hrdc Domain in Conformational Changes. Newman, J.A., Savitsky, P., Allerston, C.K., Bizard, A.H., Ozer, O., Sarlos, K., Liu, Y., Pardon, E., Steyaert, J., Hickson, I.D., Gileadi, O. Nucleic Acids Res.