CATH Classification

Domain Context

CATH Clusters

Superfamily Transferase(Phosphotransferase) domain 1
Functional Family Receptor-interacting serine/threonine-protein kinase 2

Enzyme Information

2.7.11.1
Non-specific serine/threonine protein kinase.
based on mapping to UniProt O43353
ATP + a protein = ADP + a phosphoprotein.
-!- This is a heterogeneous group of serine/threonine protein kinases that do not have an activating compound and are either non-specific or their specificity has not been analyzed to date. -!- Formerly EC 2.7.1.37 and EC 2.7.1.70.
2.7.10.2
Non-specific protein-tyrosine kinase.
based on mapping to UniProt O43353
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
-!- Unlike EC 2.7.10.1, this protein-tyrosine kinase does not have a transmembrane domain. -!- In the human genome, 32 non-specific protein-tyrosine kinases have been identified and these can be divided into 10 families. -!- Formerly EC 2.7.1.112.

UniProtKB Entries (1)

O43353
RIPK2_HUMAN
Homo sapiens
Receptor-interacting serine/threonine-protein kinase 2

PDB Structure

PDB 4C8B
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Inflammatory Signaling by NOD-RIPK2 Is Inhibited by Clinically Relevant Type II Kinase Inhibitors.
Canning, P., Ruan, Q., Schwerd, T., Hrdinka, M., Maki, J.L., Saleh, D., Suebsuwong, C., Ray, S., Brennan, P.E., Cuny, G.D., Uhlig, H.H., Gyrd-Hansen, M., Degterev, A., Bullock, A.N.
Chem. Biol.
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