CATH Domain 4c5cB02

Level	CATH Code	Description
	3	Alpha Beta
	3.30	2-Layer Sandwich
	3.30.470	D-amino Acid Aminotransferase; Chain A, domain 1
	3.30.470.20	ATP-grasp fold, B domain

Superfamily	ATP-grasp fold, B domain
Functional Family	D-alanine--D-alanine ligase

6.3.2.4

D-alanine--D-alanine ligase.

based on mapping to UniProt P07862

ATP + 2 D-alanine = ADP + phosphate + D-alanyl-D-alanine.

-!- Involved with EC 6.3.2.7 or EC 6.3.2.13, EC 6.3.2.8, EC 6.3.2.9 and EC 6.3.2.10 in the synthesis of a cell-wall peptide.

DDLB_ECOLI

Escherichia coli K-12

D-alanine--D-alanine ligase B

PDB	4C5C
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Inhibition of D-Ala:D-Ala ligase through a phosphorylated form of the antibiotic D-cycloserine. Batson, S., de Chiara, C., Majce, V., Lloyd, A.J., Gobec, S., Rea, D., Fulop, V., Thoroughgood, C.W., Simmons, K.J., Dowson, C.G., Fishwick, C.W.G., de Carvalho, L.P.S., Roper, D.I. Nat Commun