CATH Domain 4c12A03

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.90	Alpha-Beta Complex
	3.90.190	Protein-Tyrosine Phosphatase; Chain A
	3.90.190.20	Mur ligase, C-terminal domain

Domain Context

CATH Clusters

Superfamily	Mur ligase, C-terminal domain
Functional Family

Enzyme Information

6.3.2.7

UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--L-lysine ligase.

based on mapping to UniProt Q2FZP6

ATP + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamate + L-lysine = ADP + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D- glutamyl-L-lysine.

-!- Involved in the synthesis of a cell-wall peptide. -!- This enzyme adds lysine in some Gram-positive organisms; in others and in Gram-negative organisms EC 6.3.2.13 adds 2,6-diaminopimelate instead.

UniProtKB Entries (1)

Q2FZP6

MURE_STAA8

Staphylococcus aureus subsp. aureus NCTC 8325

UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--L-lysine ligase

PDB Structure

PDB	4C12
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Specificity Determinants for Lysine Incorporation in Staphylococcus Aureus Peptidoglycan as Revealed by the Structure of a Mure Enzyme Ternary Complex. Ruane, K.M., Lloyd, A.J., Fulop, V., Dowson, C.G., Barreteau, H., Boniface, A., Dementin, S., Blanot, D., Mengin-Lecreulx, D., Gobec, S., Dessen, A., Roper, D.I. J.Biol.Chem.