CATH Classification
Level | CATH Code | Description |
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1 | Mainly Alpha |
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1.10 | Orthogonal Bundle |
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1.10.630 | Cytochrome p450 |
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1.10.630.10 | Cytochrome P450 |
Domain Context
CATH Clusters
Superfamily | Cytochrome P450 |
Functional Family |
Enzyme Information
1.14.14.154 |
Sterol 14-alpha-demethylase.
based on mapping to UniProt Q7Z1V1
A 14-alpha-methylsteroid + 3 [reduced NADPH--hemoprotein reductase] + 3 O(2) = a Delta(14)-steroid + formate + 3 [oxidized NADPH--hemoprotein reductase] + 4 H(2)O.
-!- This cytochrome P450 (heme-thiolate) enzyme acts on a range of steroids with a 14-alpha-methyl group, such as obtusifoliol and lanosterol. -!- The enzyme catalyzes a hydroxylation and a reduction of the 14-alpha- methyl group, followed by a second hydroxylation, resulting in the elimination of formate and formation of a 14(15) double bond. -!- Formerly EC 1.14.13.70.
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UniProtKB Entries (1)
Q7Z1V1 |
CP51_TRYCC
Trypanosoma cruzi strain CL Brener
Sterol 14-alpha demethylase
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PDB Structure
PDB | 4BY0 |
External Links | |
Method | X-RAY DIFFRACTION |
Organism | |
Primary Citation |
R-Configuration of 4-Aminopyridyl-Based Inhibitors of Cyp51 Confers Superior Efficacy Against Trypanosoma Cruzi
Acs Med.Chem.Lett.
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