CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
1 | Mainly Alpha |
|
1.20 | Up-down Bundle |
|
1.20.120 | Four Helix Bundle (Hemerythrin (Met), subunit A) |
|
1.20.120.550 | Membrane associated eicosanoid/glutathione metabolism-like domain |
Domain Context
CATH Clusters
| Superfamily | Membrane associated eicosanoid/glutathione metabolism-like domain |
| Functional Family | Microsomal glutathione S-transferase 1 |
Enzyme Information
| 5.3.99.3 |
Prostaglandin-E synthase.
based on mapping to UniProt O14684
(5Z,13E)-(15S)-9-alpha,11-alpha-epidioxy-15-hydroxyprosta-5,13-dienoate = (5Z,13E)-(15S)-11-alpha,15-dihydroxy-9-oxoprosta-5,13-dienoate.
-!- Brings about the opening of the epidioxy bridge.
|
| 4.4.1.20 |
Leukotriene-C(4) synthase.
based on mapping to UniProt Q16873
Leukotriene C(4) = leukotriene A(4) + glutathione.
-!- The reaction proceeds in the direction of addition. -!- Not identical with EC 2.5.1.18. -!- Formerly EC 2.5.1.37.
|
UniProtKB Entries (1)
| O14684 |
PTGES_HUMAN
Homo sapiens
Prostaglandin E synthase
|
PDB Structure
| PDB | 4BPM |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Crystallizing Membrane Proteins in the Lipidic Mesophase. Experience with Human Prostaglandin E2 Synthase 1 and an Evolving Strategy.
Cryst.Growth Des.
|
