CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.40 | 3-Layer(aba) Sandwich |
|
3.40.50 | Rossmann fold |
|
3.40.50.720 | NAD(P)-binding Rossmann-like Domain |
Domain Context
CATH Clusters
| Superfamily | NAD(P)-binding Rossmann-like Domain |
| Functional Family | 3-oxoacyl-[acyl-carrier-protein] reductase FabG |
Enzyme Information
| 1.1.1.100 |
3-oxoacyl-[acyl-carrier-protein] reductase.
based on mapping to UniProt O54438
(3R)-3-hydroxyacyl-[acyl-carrier-protein] + NADP(+) = 3-oxoacyl-[acyl- carrier-protein] + NADPH.
-!- Exhibits a marked preference for [acyl-carrier-protein] derivatives over CoA derivatives as substrates.
|
UniProtKB Entries (1)
| O54438 |
FABG_PSEAE
Pseudomonas aeruginosa PAO1
3-oxoacyl-[acyl-carrier-protein] reductase FabG
|
PDB Structure
| PDB | 4BO6 |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Discovery of an Allosteric Inhibitor Binding Site in 3-Oxo-Acyl-Acp Reductase from Pseudomonas Aeruginosa
Acs Chem.Biol.
|
