CATH Domain 4bbeA01

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.30	2-Layer Sandwich
	3.30.200	Phosphorylase Kinase; domain 1
	3.30.200.20	Phosphorylase Kinase; domain 1

Domain Context

CATH Clusters

Superfamily	Phosphorylase Kinase; domain 1
Functional Family	Tyrosine-protein kinase

Enzyme Information

2.7.10.2

Non-specific protein-tyrosine kinase.

based on mapping to UniProt O60674

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.

-!- Unlike EC 2.7.10.1, this protein-tyrosine kinase does not have a transmembrane domain. -!- In the human genome, 32 non-specific protein-tyrosine kinases have been identified and these can be divided into 10 families. -!- Formerly EC 2.7.1.112.

UniProtKB Entries (1)

O60674

JAK2_HUMAN

Homo sapiens

Tyrosine-protein kinase JAK2

PDB Structure

PDB	4BBE
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Sar and in Vivo Evaluation of 4-Aryl-2-Aminoalkylpyrimidines as Potent and Selective Janus Kinase 2 (Jak2) Inhibitors Forsyth, T., Kearney, P.C., Kim, B.G., Johnson, H.W.B., Aay, N., Arcalas, A., Brown, D.S., Chan, V., Chen, J., Du, H., Epshteyn, S., Galan, A.A., Huynh, T.P., Ibrahim, M.A., Kane, B., Koltun, E., Mann, G., Meyr, L.E., Lee, M.S., Lewis, G.L., Noguchi, R.T., Pack, M., Ridgway, B.H., Shi, X., Takeuchi, C.S., Zu, P., Leahy, J.W., Nuss, J.M., Aoyama, R., Engst, S., Gendreau, S.B., Kassees, R., Li, J., Lin, S.-H., Martini, J.-F., Stout, T., Tong, P., Woolfrey, J., Zhang, W., Yu, P. Bioorg.Med.Chem.Lett.