CATH Domain 4b6cA00

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.30	2-Layer Sandwich
	3.30.565	Heat Shock Protein 90
	3.30.565.10	Histidine kinase-like ATPase, C-terminal domain

Domain Context

CATH Clusters

Superfamily	Histidine kinase-like ATPase, C-terminal domain
Functional Family

Enzyme Information

5.6.2.3

DNA topoisomerase (ATP-hydrolyzing).

based on mapping to UniProt P0C559

ATP-dependent breakage, passage and rejoining of double-stranded DNA.

-!- The enzyme can introduce negative superhelical turns into double- stranded circular DNA. -!- One unit has nicking-closing activity, and another catalyzes super- twisting and hydrolysis of ATP (cf. EC 5.6.2.2). -!- Formerly EC 5.99.1.3.

UniProtKB Entries (1)

P0C559

GYRB_MYCSM

Mycolicibacterium smegmatis

DNA gyrase subunit B

PDB Structure

PDB	4B6C
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Aminopyrazinamides: novel and specific GyrB inhibitors that kill replicating and nonreplicating Mycobacterium tuberculosis. Shirude, P.S., Madhavapeddi, P., Tucker, J.A., Murugan, K., Patil, V., Basavarajappa, H., Raichurkar, A.V., Humnabadkar, V., Hussein, S., Sharma, S., Ramya, V.K., Narayan, C.B., Balganesh, T.S., Sambandamurthy, V.K. ACS Chem. Biol.