CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
1 | Mainly Alpha |
|
1.10 | Orthogonal Bundle |
|
1.10.510 | Transferase(Phosphotransferase); domain 1 |
|
1.10.510.10 | Transferase(Phosphotransferase) domain 1 |
Domain Context
CATH Clusters
| Superfamily | Transferase(Phosphotransferase) domain 1 |
| Functional Family | dual specificity tyrosine-phosphorylation-regulated kinase 1A isoform X1 |
Enzyme Information
| 2.7.12.1 |
Dual-specificity kinase.
based on mapping to UniProt Q13627
ATP + a protein = ADP + a phosphoprotein.
-!- This family of enzymes can phosphorylate both Ser/Thr and Tyr residues. -!- Formerly EC 2.7.1.37.
|
UniProtKB Entries (1)
| Q13627 |
DYR1A_HUMAN
Homo sapiens
Dual specificity tyrosine-phosphorylation-regulated kinase 1A
|
PDB Structure
| PDB | 4AZE |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Selectivity, Co-Crystal Structures and Neuroprotective Properties of Leucettines, a Family of Protein Kinase Inhibitors Derived from the Marine Sponge Alkaloid Leucettamine B.
J.Med.Chem.
|