CATH Domain 4anmA01

CATH Classification

Level	CATH Code	Description
	1	Mainly Alpha
	1.10	Orthogonal Bundle
	1.10.510	Transferase(Phosphotransferase); domain 1
	1.10.510.10	Transferase(Phosphotransferase) domain 1

Domain Context

CATH Clusters

Superfamily	Transferase(Phosphotransferase) domain 1
Functional Family	Casein kinase II subunit alpha

Enzyme Information

2.7.11.1

Non-specific serine/threonine protein kinase.

based on mapping to UniProt P28523

ATP + a protein = ADP + a phosphoprotein.

-!- This is a heterogeneous group of serine/threonine protein kinases that do not have an activating compound and are either non-specific or their specificity has not been analyzed to date. -!- Formerly EC 2.7.1.37 and EC 2.7.1.70.

UniProtKB Entries (1)

P28523

CSK2A_MAIZE

Zea mays

Casein kinase II subunit alpha

PDB Structure

PDB	4ANM
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Discovery of Xl413, a Potent and Selective Cdc7 Inhibitor. Koltun, E.S., Tsuhako, A.L., Brown, D.S., Aay, N., Arcalas, A., Chan, V., Du, H., Engst, S., Ferguson, K., Franzini, M., Galan, A., Holst, C.R., Huang, P., Kane, B., Kim, M.H., Li, J., Markby, D., Mohan, M., Noson, K., Plonowski, A., Richards, S.J., Robertson, S., Shaw, K., Stott, G., Stout, T.J., Young, J., Yu, P., Zaharia, C.A., Zhang, W., Zhou, P., Nuss, J.M., Xu, W., Kearney, P.C. Bioorg.Med.Chem.Lett.