CATH Domain 4a7cA01

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.30	2-Layer Sandwich
	3.30.200	Phosphorylase Kinase; domain 1
	3.30.200.20	Phosphorylase Kinase; domain 1

Domain Context

CATH Clusters

Superfamily	Phosphorylase Kinase; domain 1
Functional Family	Serine/threonine-protein kinase pim-1

Enzyme Information

2.7.11.1

Non-specific serine/threonine protein kinase.

based on mapping to UniProt P11309

ATP + a protein = ADP + a phosphoprotein.

-!- This is a heterogeneous group of serine/threonine protein kinases that do not have an activating compound and are either non-specific or their specificity has not been analyzed to date. -!- Formerly EC 2.7.1.37 and EC 2.7.1.70.

UniProtKB Entries (1)

P11309

PIM1_HUMAN

Homo sapiens

Serine/threonine-protein kinase pim-1

PDB Structure

PDB	4A7C
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Hit to Lead Evaluation of 1,2,3-Triazolo[4,5-B]Pyridines as Pim Kinase Inhibitors. Pastor, J., Oyarzabal, J., Saluste, G., Alvarez, R.M., Rivero, V., Ramos, F., Cendon, E., Blanco-Aparicio, C., Ajenjo, N., Cebria, A., Albarran, M.I., Cebrian, D., Corrionero, A., Fominaya, J., Montoya, G., Mazzorana, M. Bioorg.Med.Chem.Lett.