CATH Classification
Level | CATH Code | Description |
---|---|---|
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3 | Alpha Beta |
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3.40 | 3-Layer(aba) Sandwich |
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3.40.50 | Rossmann fold |
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3.40.50.720 | NAD(P)-binding Rossmann-like Domain |
Domain Context
CATH Clusters
Superfamily | NAD(P)-binding Rossmann-like Domain |
Functional Family |
Enzyme Information
1.1.1.27 |
L-lactate dehydrogenase.
based on mapping to UniProt Q5SJA1
(S)-lactate + NAD(+) = pyruvate + NADH.
-!- Also oxidizes other (S)-2-hydroxymonocarboxylic acids. -!- NADP(+) acts, more slowly, with the animal, but not the bacterial, enzyme.
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UniProtKB Entries (1)
Q5SJA1 |
LDH_THET8
Thermus thermophilus HB8
L-lactate dehydrogenase
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PDB Structure
PDB | 4A73 |
External Links | |
Method | X-RAY DIFFRACTION |
Organism | |
Primary Citation |
Sampling the Conformational Energy Landscape of a Hyperthermophilic Protein by Engineering Key Substitutions
Mol.Biol.Evol.
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