CATH Domain 4a22A00

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.20	Alpha-Beta Barrel
	3.20.20	TIM Barrel
	3.20.20.70	Aldolase class I

Domain Context

CATH Clusters

Superfamily	Aldolase class I
Functional Family	Fructose-bisphosphate aldolase Fba

Enzyme Information

4.1.2.13

Fructose-bisphosphate aldolase.

based on mapping to UniProt P9WQA3

D-fructose 1,6-bisphosphate = glycerone phosphate + D-glyceraldehyde 3-phosphate.

-!- Also acts on (3S,4R)-ketose 1-phosphates. -!- The enzymes increase electron-attraction by the carbonyl group, some (Class I) forming a protonated imine with it, others (Class II), mainly of microbial origin, polarizing it with a metal ion, e.g. zinc. -!- Formerly EC 4.1.2.7.

UniProtKB Entries (1)

P9WQA3

ALF_MYCTU

Mycobacterium tuberculosis H37Rv

Fructose-bisphosphate aldolase

PDB Structure

PDB	4A22
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Glycolytic and non-glycolytic functions of Mycobacterium tuberculosis fructose-1,6-bisphosphate aldolase, an essential enzyme produced by replicating and non-replicating bacilli. de la Paz Santangelo, M., Gest, P.M., Guerin, M.E., Coincon, M., Pham, H., Ryan, G., Puckett, S.E., Spencer, J.S., Gonzalez-Juarrero, M., Daher, R., Lenaerts, A.J., Schnappinger, D., Therisod, M., Ehrt, S., Sygusch, J., Jackson, M. J. Biol. Chem.