CATH Domain 3znsA00

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.40	3-Layer(aba) Sandwich
	3.40.800	Arginase; Chain A
	3.40.800.20	Histone deacetylase domain

Domain Context

CATH Clusters

Superfamily	Histone deacetylase domain
Functional Family	Histone deacetylase

Enzyme Information

3.5.1.98

Histone deacetylase.

based on mapping to UniProt Q8WUI4

Hydrolysis of an N(6)-acetyl-lysine residue of a histone to yield a deacetylated histone.

-!- A class of enzymes that remove acetyl groups from N(6)-acetyl-lysine residues on a histone. -!- The reaction of this enzyme is opposite to that of EC 2.3.1.48. -!- Histone deacetylases (HDACs) can be organized into three classes depending on sequence similarity and domain organization. -!- Histone acetylation plays an important role in regulation of gene expression. -!- In eukaryotes, HDACs play a key role in the regulation of transcription and cell proliferation. -!- May be identical to EC 3.5.1.17.

UniProtKB Entries (1)

Q8WUI4

HDAC7_HUMAN

Homo sapiens

Histone deacetylase 7

PDB Structure

PDB	3ZNS
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Selective Class Iia Histone Deacetylase Inhibition Via a Non-Chelating Zinc Binding Group Lobera, M., Madauss, K.P., Pohlhaus, D.T., Wright, Q.G., Trocha, M., Schmidt, D.R., Baloglu, E., Trump, R.P., Head, M.S., Hofmann, G.A., Murray-Thompson, M., Schwartz, B., Chakravorty, S., Wu, Z., Mander, P.K., Kruidenier, L., Reid, R.A., Burkhart, W., Turunen, B.J., Rong, J.X., Wagner, C., Moyer, M.B., Wells, C., Hong, X., Moore, J.T., Williams, J.D., Soler, D., Ghosh, S., Nolan, M.A. Nat.Chem.Biol.