CATH Domain 3zjtA01

CATH Classification

Level	CATH Code	Description
	1	Mainly Alpha
	1.10	Orthogonal Bundle
	1.10.730	Isoleucyl-tRNA Synthetase; Domain 1
	1.10.730.10	Isoleucyl-tRNA Synthetase; Domain 1

Domain Context

CATH Clusters

Superfamily	Isoleucyl-tRNA Synthetase; Domain 1
Functional Family	Leucine--tRNA ligase

Enzyme Information

6.1.1.4

Leucine--tRNA ligase.

based on mapping to UniProt P07813

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).

UniProtKB Entries (1)

SYL_ECOLI

Escherichia coli K-12

Leucine--tRNA ligase

PDB Structure

PDB	3ZJT
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Discovery of a Novel Class of Boron-Based Antibacterials with Activity Against Gram-Negative Bacteria. Hernandez, V., Crepin, T., Palencia, A., Cusack, S., Akama, T., Baker, S.J., Bu, W., Feng, L., Freund, Y.R., Liu, L., Meewan, M., Mohan, M., Mao, W., Rock, F.L., Sexton, H., Sheoran, A., Zhang, Y., Zhang, Y., Zhou, Y., Nieman, J.A., Anugula, M.R., Keramane, E.M., Savariraj, K., Reddy, D.S., Sharma, R., Subedi, R., Singh, R., O'Leary, A., Simon, N.L., De Marsh, P.L., Mushtaq, S., Warner, M., Livermore, D.M., Alley, M.R.K., Plattner, J.J. Antimicrob.Agents Chemother.