CATH Classification

Domain Context

CATH Clusters

Superfamily Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal
Functional Family L-lactate dehydrogenase

Enzyme Information

1.1.1.27
L-lactate dehydrogenase.
based on mapping to UniProt Q76NM3
(S)-lactate + NAD(+) = pyruvate + NADH.
-!- Also oxidizes other (S)-2-hydroxymonocarboxylic acids. -!- NADP(+) acts, more slowly, with the animal, but not the bacterial, enzyme.

UniProtKB Entries (1)

Q76NM3
Q76NM3_PLAF7
Plasmodium falciparum 3D7
L-lactate dehydrogenase

PDB Structure

PDB 3ZH2
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structural Basis for Discriminatory Recognition of Plasmodium Lactate Dehydrogenase by a DNA Aptamer
Cheung, Y.W., Kwok, J., Law, A.W.L., Watt, R.M., Kotaka, M., Tanner, J.A.
Proc.Natl.Acad.Sci.USA