CATH Domain 3zdnA01

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.50	3-Layer(bba) Sandwich
	3.50.50	FAD/NAD(P)-binding domain
	3.50.50.60	FAD/NAD(P)-binding domain

Domain Context

CATH Clusters

Superfamily	FAD/NAD(P)-binding domain
Functional Family

Enzyme Information

1.4.3.4

Monoamine oxidase.

based on mapping to UniProt P46882

RCH(2)NHR' + H(2)O + O(2) = RCHO + R'NH(2) + H(2)O(2).

-!- Catalyzes the oxidative deamination of neurotransmitters and biogenic amines. -!- Acts on primary amines, and also on some secondary and tertiary amines. -!- It differs from EC 1.4.3.21, as it can oxidize secondary and tertiary amines but not methylamine. -!- Inhibited by acetylenic compounds such as chlorgyline, 1-deprenyl and pargyline but, unlike EC 1.4.3.21 and EC 1.4.3.22, it is not inhibited by semicarbazide. -!- Formerly EC 1.4.3.9.

UniProtKB Entries (1)

P46882

AOFN_ASPNG

Aspergillus niger

Monoamine oxidase N

PDB Structure

PDB	3ZDN
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Engineering an Enantioselective Amine Oxidase for the Synthesis of Pharmaceutical Building Blocks and Alkaloid Natural Products. Ghislieri, D., Green, A.P., Pontini, M., Willies, S.C., Rowles, I., Frank, A., Grogan, G., Turner, N.J. J.Am.Chem.Soc.