CATH Domain 3zbfA02

CATH Classification

Level	CATH Code	Description
	1	Mainly Alpha
	1.10	Orthogonal Bundle
	1.10.510	Transferase(Phosphotransferase); domain 1
	1.10.510.10	Transferase(Phosphotransferase) domain 1

Domain Context

CATH Clusters

Superfamily	Transferase(Phosphotransferase) domain 1
Functional Family	Tyrosine-protein kinase receptor

Enzyme Information

2.7.10.1

Receptor protein-tyrosine kinase.

based on mapping to UniProt P08922

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.

-!- The receptor protein-tyrosine kinases, which can be defined as having a transmembrane domain, are a large and diverse multigene family found only in metazoans. -!- In the human genome, 58 receptor-type protein-tyrosine kinases have been identified and these are distributed into 20 subfamilies. -!- Formerly EC 2.7.1.112.

UniProtKB Entries (1)

P08922

ROS1_HUMAN

Homo sapiens

Proto-oncogene tyrosine-protein kinase ROS

PDB Structure

PDB	3ZBF
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Acquired Resistance to Crizotinib from a Mutation in Cd74-Ros1 Awad, M.M., Katayama, R., Mctigue, M., Liu, W., Deng, Y., Brooun, A., Friboulet, L., Huang, D., Falk, M.D., Timofeevski, S., Wilner, K.D., Lockerman, E.L., Khan, T.M., Mahmood, S., Gainor, J.F., Digumarthy, S.R., Stone, J.R., Mino-Kenudson, M., Christensen, J.G., Iafrate, J., Engelman, J.A., Shaw, A.T. N.Engl.J.Med.