CATH Classification
Level | CATH Code | Description |
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3 | Alpha Beta |
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3.40 | 3-Layer(aba) Sandwich |
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3.40.1180 | Undecaprenyl pyrophosphate synthetase |
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3.40.1180.10 | Decaprenyl diphosphate synthase-like |
Domain Context
CATH Clusters
Superfamily | Decaprenyl diphosphate synthase-like |
Functional Family | Diterpene synthase |
Enzyme Information
3.1.7.8 |
Tuberculosinol synthase.
based on mapping to UniProt P9WJ61
Tuberculosinyl diphosphate + H(2)O = tuberculosinol + diphosphate.
-!- Only found in species of Mycobacterium that cause tuberculosis. -!- In addition, it also gives isotuberculosinol in 1:1 mixture, cf. EC 3.1.7.9.
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3.1.7.9 |
Isotuberculosinol synthase.
based on mapping to UniProt P9WJ61
Tuberculosinyl diphosphate + H(2)O = (13S)-isotuberculosinol + diphosphate.
-!- Only found in species of Mycobacterium that cause tuberculosis. -!- In addition, it also gives tuberculosinol in 1:1 mixture, cf EC 3.1.7.8. -!- The isotuberculosinol form was a 3:1 mixture of the 13S and 13R forms, respectively.
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UniProtKB Entries (1)
P9WJ61 |
TUBOL_MYCTU
Mycobacterium tuberculosis H37Rv
Diterpene synthase
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PDB Structure
PDB | 3WQK |
External Links | |
Method | X-RAY DIFFRACTION |
Organism | |
Primary Citation |
Structure and inhibition of tuberculosinol synthase and decaprenyl diphosphate synthase from Mycobacterium tuberculosis.
J.Am.Chem.Soc.
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