CATH Classification
Level | CATH Code | Description |
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2 | Mainly Beta |
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2.30 | Roll |
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2.30.26 | Dihydroorotate Dehydrogenase A; chain A, domain 2 |
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2.30.26.10 | Dihydroorotate Dehydrogenase A, chain A, domain 2 |
Domain Context
CATH Clusters
Superfamily | Dihydroorotate Dehydrogenase A, chain A, domain 2 |
Functional Family | Dihydroorotate dehydrogenase (fumarate) |
Enzyme Information
1.3.98.1 |
Dihydroorotate oxidase (fumarate).
based on mapping to UniProt Q4D3W2
(S)-dihydroorotate + fumarate = orotate + succinate.
-!- The reaction, which takes place in the cytosol, is the only redox reaction in the de novo biosynthesis of pyrimidine nucleotides. -!- Molecular oxygen can replace fumarate in vitro. -!- Other class 1 dihydroorotate dehydrogenases use either NAD(+) (EC 1.3.1.14) or NADP(+) (EC 1.3.1.15) as electron acceptor. -!- The membrane bound class 2 dihydroorotate dehydrogenase (EC 1.3.5.2) uses quinone as electron acceptor. -!- Formerly EC 1.3.3.1.
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UniProtKB Entries (1)
Q4D3W2 |
PYRD_TRYCC
Trypanosoma cruzi strain CL Brener
Dihydroorotate dehydrogenase (fumarate)
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PDB Structure
PDB | 3W88 |
External Links | |
Method | X-RAY DIFFRACTION |
Organism | |
Primary Citation |
Structure of Trypanosoma cruzi dihydroorotate dehydrogenase in complex with SH-1-200
To be Published
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