CATH Classification

Domain Context

CATH Clusters

Superfamily 2.170.220.10
Functional Family methionine--tRNA ligase, mitochondrial

Enzyme Information

6.1.1.10
Methionine--tRNA ligase.
based on mapping to UniProt P23395
ATP + L-methionine + tRNA(Met) = AMP + diphosphate + L-methionyl- tRNA(Met).
-!- In those organisms producing N-formylmethionyl-tRNA(fMet) for translation initiation, this enzyme also recognizes the initiator tRNA(fMet) and catalyzes the formation of L-methionyl-tRNA(fMet), the substrate for EC 2.1.2.9.

UniProtKB Entries (1)

P23395
SYM_THET8
Thermus thermophilus HB8
Methionine--tRNA ligase

PDB Structure

PDB 3VU8
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
The modeling of structures of specific conformation of homosysteine-AMP leading to thiolactone-formation on class Ia aminoacyl-tRNA synthetases
Konno, M., Kato-Murayama, M., Takeda, R., Takasaka, R., Uchikawa, E., Toma-Fukai, S., Ishii, R., Nureki, O., Yokoyama, S.
To be Published