CATH Classification
Level | CATH Code | Description |
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3 | Alpha Beta |
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3.30 | 2-Layer Sandwich |
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3.30.420 | Nucleotidyltransferase; domain 5 |
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3.30.420.40 | ATPase, nucleotide binding domain |
Domain Context
CATH Clusters
Superfamily | 3.30.420.40 |
Functional Family |
Enzyme Information
6.1.2.2 |
Nebramycin 5' synthase.
based on mapping to UniProt Q70IY1
(1) Tobramycin + carbamoyl phosphate + ATP + H(2)O = nebramycin 5' + AMP + diphosphate + phosphate. (2) Kanamycin A + carbamoyl phosphate + ATP + H(2)O = 6''-O- carbamoylkanamycin A + AMP + diphosphate + phosphate.
-!- The enzyme from the bacterium Streptoalloteichus tenebrarius catalyzes the activation of carbamoyl phosphate to O-carbamoyladenylate and the subsequent carbamoylation of kanamycin and tobramycin. -!- Formerly EC 2.1.3.13 and EC 2.1.3.14.
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UniProtKB Entries (1)
Q70IY1 |
TOBZ_STRSD
Streptoalloteichus tenebrarius
Nebramycin 5' synthase
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PDB Structure
PDB | 3VET |
External Links | |
Method | X-RAY DIFFRACTION |
Organism | |
Primary Citation |
The O-Carbamoyltransferase TobZ Catalyzes an Ancient Enzymatic Reaction.
Angew.Chem.Int.Ed.Engl.
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