CATH Classification

Domain Context

CATH Clusters

Superfamily 3.10.450.60
Functional Family Arachidonate 5-lipoxygenase a

Enzyme Information

1.13.11.34
Arachidonate 5-lipoxygenase.
based on mapping to UniProt P09917
Arachidonate + O(2) = leukotriene A(4) + H(2)O.

UniProtKB Entries (1)

P09917
LOX5_HUMAN
Homo sapiens
Arachidonate 5-lipoxygenase

PDB Structure

PDB 3V99
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Conversion of human 5-lipoxygenase to a 15-lipoxygenase by a point mutation to mimic phosphorylation at Serine-663.
Gilbert, N.C., Rui, Z., Neau, D.B., Waight, M.T., Bartlett, S.G., Boeglin, W.E., Brash, A.R., Newcomer, M.E.
Faseb J.