CATH Classification
Level | CATH Code | Description |
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3 | Alpha Beta |
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3.30 | 2-Layer Sandwich |
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3.30.210 | Beta Polymerase; domain 3 |
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3.30.210.10 | DNA polymerase, thumb domain |
Domain Context
CATH Clusters
Superfamily | DNA polymerase, thumb domain |
Functional Family | DNA polymerase beta |
Enzyme Information
4.2.99.- |
Other carbon-oxygen lyases.
based on mapping to UniProt P06766
|
2.7.7.7 |
DNA-directed DNA polymerase.
based on mapping to UniProt P06766
Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).
-!- Catalyzes DNA-template-directed extension of the 3'-end of a DNA strand by one nucleotide at a time. -!- Cannot initiate a chain de novo. -!- Requires a primer which may be DNA or RNA. -!- See also EC 2.7.7.49.
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UniProtKB Entries (1)
P06766 |
DPOLB_RAT
Rattus norvegicus
DNA polymerase beta
|
PDB Structure
PDB | 3UXO |
External Links | |
Method | X-RAY DIFFRACTION |
Organism | |
Primary Citation |
Structural Changes in the Hydrophobic Hinge Region Adversely Affect the Activity and Fidelity of the I260Q Mutator DNA Polymerase beta.
Biochemistry
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