CATH Domain 3uriA01

CATH Classification

Level	CATH Code	Description
	2	Mainly Beta
	2.40	Beta Barrel
	2.40.70	Cathepsin D, subunit A; domain 1
	2.40.70.10	Acid Proteases

Domain Context

CATH Clusters

Superfamily	Acid Proteases
Functional Family	Endothiapepsin

Enzyme Information

3.4.23.22

Endothiapepsin.

based on mapping to UniProt P11838

Hydrolysis of proteins with specificity similar to that of pepsin A, prefers hydrophobic residues at P1 and P1', but does not cleave 14-Ala-|-Leu-15 in the B chain of insulin or Z-Glu-Tyr. Clots milk.

-!- From the ascomycete Endothia parasitica. -!- Belongs to peptidase family A1. -!- Formerly EC 3.4.4.17, EC 3.4.23.6 and EC 3.4.23.10.

UniProtKB Entries (1)

P11838

CARP_CRYPA

Cryphonectria parasitica

Endothiapepsin

PDB Structure

PDB	3URI
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	An analysis of subdomain orientation, conformational change and disorder in relation to crystal packing of aspartic proteinases. Bailey, D., Carpenter, E.P., Coker, A., Coker, S., Read, J., Jones, A.T., Erskine, P., Aguilar, C.F., Badasso, M., Toldo, L., Rippmann, F., Sanz-Aparicio, J., Albert, A., Blundell, T.L., Roberts, N.B., Wood, S.P., Cooper, J.B. Acta Crystallogr.,Sect.D