CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.30 | 2-Layer Sandwich |
|
3.30.60 | Wheat Germ Agglutinin (Isolectin 2); domain 1 |
|
3.30.60.20 |
Domain Context
CATH Clusters
| Superfamily | 3.30.60.20 |
| Functional Family | Protein kinase C delta |
Enzyme Information
| 2.7.10.2 |
Non-specific protein-tyrosine kinase.
based on mapping to UniProt P28867
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
-!- Unlike EC 2.7.10.1, this protein-tyrosine kinase does not have a transmembrane domain. -!- In the human genome, 32 non-specific protein-tyrosine kinases have been identified and these can be divided into 10 families. -!- Formerly EC 2.7.1.112.
|
| 2.7.11.13 |
Protein kinase C.
based on mapping to UniProt P28867
ATP + a protein = ADP + a phosphoprotein.
-!- A family of serine- and threonine-specific protein kinases that depend on lipids for activity. -!- They can be activated by calcium but have a requirement for the second messenger diacylglycerol. -!- Members of this group of enzymes phosphorylate a wide variety of protein targets and are known to be involved in diverse cell- signaling pathways. -!- Members of the protein kinase C family also serve as major receptors for phorbol esters, a class of tumor promoters. -!- Formerly EC 2.7.1.37.
|
UniProtKB Entries (1)
| P28867 |
KPCD_MOUSE
Mus musculus
Protein kinase C delta type
|
PDB Structure
| PDB | 3UGL |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Structural and Functional Characterization of an Anesthetic Binding Site in the Second Cysteine-Rich Domain of Protein Kinase Cdelta
Biophys.J.
|
