CATH Classification
Domain Context
CATH Clusters
| Superfamily | Spore Coat Polysaccharide Biosynthesis Protein SpsA; Chain A |
| Functional Family | Histo-blood group ABO system transferase |
Enzyme Information
| 2.4.1.37 |
Fucosylgalactoside 3-alpha-galactosyltransferase.
based on mapping to UniProt P16442
UDP-alpha-D-galactose + alpha-L-fucosyl-(1->2)-D-galactosyl-R = UDP + alpha-D-galactosyl-(1->3)-(alpha-L-fucosyl-(1->2))-D-galactosyl-R.
-!- Acts on blood group substance, and can use a number of 2-fucosyl- galactosides as acceptors.
|
| 2.4.1.40 |
Glycoprotein-fucosylgalactoside alpha-N-acetylgalactosaminyltransferase.
based on mapping to UniProt P16442
UDP-N-acetyl-alpha-beta-D-galactosamine + glycoprotein-alpha-L-fucosyl- (1->2)-D-galactose = UDP + glycoprotein-N-acetyl-alpha-D-galactosaminyl- (1->3)-(alpha-L-fucosyl-(1->2))-beta-D-galactose.
-!- Acts on blood group substance H. -!- Can use a number of 2-fucosyl-galactosides as acceptors.
|
UniProtKB Entries (1)
| P16442 |
BGAT_HUMAN
Homo sapiens
Histo-blood group ABO system transferase
|
PDB Structure
| PDB | 3U0X |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
A novel compound from a molecular fragment library screen inhibits glycosyltransferases by displacing the metal ion and interfering with substrate binding
To be Published
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