CATH Domain 3txoA01

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.30	2-Layer Sandwich
	3.30.200	Phosphorylase Kinase; domain 1
	3.30.200.20	Phosphorylase Kinase; domain 1

Domain Context

CATH Clusters

Superfamily	Phosphorylase Kinase; domain 1
Functional Family	Protein kinase C

Enzyme Information

2.7.11.13

Protein kinase C.

based on mapping to UniProt P24723

ATP + a protein = ADP + a phosphoprotein.

-!- A family of serine- and threonine-specific protein kinases that depend on lipids for activity. -!- They can be activated by calcium but have a requirement for the second messenger diacylglycerol. -!- Members of this group of enzymes phosphorylate a wide variety of protein targets and are known to be involved in diverse cell- signaling pathways. -!- Members of the protein kinase C family also serve as major receptors for phorbol esters, a class of tumor promoters. -!- Formerly EC 2.7.1.37.

UniProtKB Entries (1)

P24723

KPCL_HUMAN

Homo sapiens

Protein kinase C eta type

PDB Structure

PDB	3TXO
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	2,6-Naphthyridines as potent and selective inhibitors of the novel protein kinase C isozymes. van Eis, M.J., Evenou, J.P., Floersheim, P., Gaul, C., Cowan-Jacob, S.W., Monovich, L., Rummel, G., Schuler, W., Stark, W., Strauss, A., Matt, A., Vangrevelinghe, E., Wagner, J., Soldermann, N. Bioorg.Med.Chem.Lett.