CATH Domain 3tvxA00

CATH Classification

Level	CATH Code	Description
	1	Mainly Alpha
	1.10	Orthogonal Bundle
	1.10.1300	Catalytic domain of cyclic nucleotide phosphodiesterase 4b2b
	1.10.1300.10	3'5'-cyclic nucleotide phosphodiesterase, catalytic domain

Domain Context

CATH Clusters

Superfamily	3'5'-cyclic nucleotide phosphodiesterase, catalytic domain
Functional Family	Phosphodiesterase

Enzyme Information

3.1.4.53

3',5'-cyclic-AMP phosphodiesterase.

based on mapping to UniProt P27815

Adenosine 3',5'-cyclic phosphate + H(2)O = adenosine 5'-phosphate.

-!- Specific for 3',5'-cAMP and does not hydrolyze other nucleoside 3',5'-cyclic phosphates such as cGMP (cf. EC 3.1.4.17 and EC 3.1.4.35). -!- It is involved in modulation of the levels of cAMP, which is a mediator in the processes of cell transformation and proliferation. -!- Formerly EC 3.1.4.n1.

UniProtKB Entries (1)

P27815

PDE4A_HUMAN

Homo sapiens

CAMP-specific 3',5'-cyclic phosphodiesterase 4A

PDB Structure

PDB	3TVX
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Fragment-Based Screening for Inhibitors of PDE4A Using Enthalpy Arrays and X-ray Crystallography. Recht, M.I., Sridhar, V., Badger, J., Hernandez, L., Chie-Leon, B., Nienaber, V., Torres, F.E. J Biomol Screen