CATH Classification
Level | CATH Code | Description |
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1 | Mainly Alpha |
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1.10 | Orthogonal Bundle |
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1.10.1840 | main proteinase (3clpro) structure, domain 3 |
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1.10.1840.10 | main proteinase (3clpro) structure, domain 3 |
Domain Context
CATH Clusters
Superfamily | main proteinase (3clpro) structure, domain 3 |
Functional Family |
Enzyme Information
3.4.19.12 |
Ubiquitinyl hydrolase 1.
based on mapping to UniProt P0C6U6
Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).
-!- Links to polypeptides smaller than 60 residues are hydrolyzed more readily than those to larger polypeptides. -!- Isoforms exist with quantitatively different specificities among the best known being UCH-L1 and UCH-L3, major proteins of the brain of mammals. -!- Inhibited by ubiquitin aldehyde (in which Gly76 is replaced by aminoacetaldehyde). -!- Belongs to peptidase family C12.
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3.4.22.- |
Cysteine endopeptidases.
based on mapping to UniProt P0C6U6
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UniProtKB Entries (1)
P0C6U6 |
R1A_CVHNL
Human coronavirus NL63
Replicase polyprotein 1a
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PDB Structure
PDB | 3TLO |
External Links | |
Method | X-RAY DIFFRACTION |
Organism | |
Primary Citation |
Crystal structure of human coronavirus NL63 3C-like protease
To be Published
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