CATH Domain 3tkaA01

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.40	3-Layer(aba) Sandwich
	3.40.50	Rossmann fold
	3.40.50.150	Vaccinia Virus protein VP39

Domain Context

CATH Clusters

Superfamily	Vaccinia Virus protein VP39
Functional Family	Ribosomal RNA small subunit methyltransferase H

Enzyme Information

2.1.1.199

16S rRNA (cytosine(1402)-N(4))-methyltransferase.

based on mapping to UniProt P60390

S-adenosyl-L-methionine + cytosine(1402) in 16S rRNA = S-adenosyl-L- homocysteine + N(4)-methylcytosine(1402) in 16S rRNA.

-!- RsmH catalyzes the N(4)-methylation of cytosine(1402) and RsmI (EC 2.1.1.198) catalyzes the 2'-O-methylation of cytosine(1402) in 16S rRNA. -!- Both methylations are necessary for efficient translation initiation at the UUG and GUG codons.

UniProtKB Entries (1)

P60390

RSMH_ECOLI

Escherichia coli K-12

Ribosomal RNA small subunit methyltransferase H

PDB Structure

PDB	3TKA
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Crystal and solution structures of methyltransferase RsmH provide basis for methylation of C1402 in 16S rRNA. Wei, Y., Zhang, H., Gao, Z.Q., Wang, W.J., Shtykova, E.V., Xu, J.H., Liu, Q.S., Dong, Y.H. J.Struct.Biol.