CATH Domain 3tjpA04

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.30	2-Layer Sandwich
	3.30.1010	Phosphatidylinositol 3-kinase Catalytic Subunit; Chain A, domain 4
	3.30.1010.10	Phosphatidylinositol 3-kinase Catalytic Subunit; Chain A, domain 4

Domain Context

CATH Clusters

Superfamily	Phosphatidylinositol 3-kinase Catalytic Subunit; Chain A, domain 4
Functional Family	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma

Enzyme Information

2.7.1.153	Phosphatidylinositol-4,5-bisphosphate 3-kinase. based on mapping to UniProt P48736 ATP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate = ADP + 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate. -!- This enzyme also catalyzes the phosphorylation of PtdIns4P to PtdIns(3,4)P(2), and of PtdIns to PtdIns3P.
2.7.11.1	Non-specific serine/threonine protein kinase. based on mapping to UniProt P48736 ATP + a protein = ADP + a phosphoprotein. -!- This is a heterogeneous group of serine/threonine protein kinases that do not have an activating compound and are either non-specific or their specificity has not been analyzed to date. -!- Formerly EC 2.7.1.37 and EC 2.7.1.70.

UniProtKB Entries (1)

PK3CG_HUMAN

Homo sapiens

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform

PDB Structure

PDB	3TJP
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	The Identification of 5-(2,4-dimorpholinopyrimidin-6-yl)-4-(trifluoromethyl)pyridin-2-amine (NVP-BKM120) as a Potent, Selective and Orally Bioavailable Class I PI3 Kinase Inhibitor for the Treatment of Cancer Burger, M.T., Pecchi, S., Wagman, A., Ni, Z.-J., Knapp, M.S., Hendrickson, T., Atallah, G., Pfister, K., Yanchen, Z., Bartulis, S., Frazier, K., Ng, S., Smith, A., Verhagen, J., Haznedar, J., Huh, K., Iwanowicz, E., Xin, X., Menezes, D., Merritt, H., Lee, I., Weisman, M., Kaufman, S., Crawford, K., Chin, M., Bussiere, D., Shoemaker, K., Zaror, I., Maira, M., Voliva, C. To be Published