CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
2 | Mainly Beta |
|
2.60 | Sandwich |
|
2.60.120 | Jelly Rolls |
|
2.60.120.1520 |
Domain Context
CATH Clusters
| Superfamily | 2.60.120.1520 |
| Functional Family | Alkylated DNA repair protein alkB homolog 8 |
Enzyme Information
| 2.1.1.229 |
tRNA (carboxymethyluridine(34)-5-O)-methyltransferase.
based on mapping to UniProt Q96BT7
S-adenosyl-L-methionine + carboxymethyluridine(34) in tRNA = S-adenosyl- L-homocysteine + 5-(2-methoxy-2-oxoethyl)uridine(34) in tRNA.
-!- The enzyme catalyzes the posttranslational modification of uridine residues at the wobble position 34 of the anticodon loop of tRNA.
|
| 1.14.11.- |
With 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors.
based on mapping to UniProt Q96BT7
|
UniProtKB Entries (1)
| Q96BT7 |
ALKB8_HUMAN
Homo sapiens
Alkylated DNA repair protein alkB homolog 8
|
PDB Structure
| PDB | 3THT |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Crystal structure and RNA binding properties of the RNA recognition motif (RRM) and AlkB domains in human AlkB homolog 8 (ABH8), an enzyme catalyzing tRNA hypermodification.
J.Biol.Chem.
|