CATH Domain 3thbA02

CATH Classification

Level	CATH Code	Description
	1	Mainly Alpha
	1.10	Orthogonal Bundle
	1.10.510	Transferase(Phosphotransferase); domain 1
	1.10.510.10	Transferase(Phosphotransferase) domain 1

Domain Context

CATH Clusters

Superfamily	Transferase(Phosphotransferase) domain 1
Functional Family	Serine/threonine-protein kinase PLK

Enzyme Information

2.7.11.21

Polo kinase.

based on mapping to UniProt P53350

ATP + a protein = ADP + a phosphoprotein.

-!- The enzyme associates with the spindle pole during mitosis and is thought to play an important role in the dynamic function of the mitotic spindle during chromosome segregation. -!- The human form of the enzyme, Plk1, does not phosphorylate histone H1, enolase and phosvitin but it can phosphorylate myelin basic protein and microtubule-associated protein MAP-2, although to a lesser extent than casein. -!- Formerly EC 2.7.1.37.

UniProtKB Entries (1)

P53350

PLK1_HUMAN

Homo sapiens

Serine/threonine-protein kinase PLK1

PDB Structure

PDB	3THB
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Discovery of a Potent and Orally Bioavailable Benzolactam-Derived Inhibitor of Polo-Like Kinase 1 (MLN0905). Duffey, M.O., Vos, T.J., Adams, R., Alley, J., Anthony, J., Barrett, C., Bharathan, I., Bowman, D., Bump, N.J., Chau, R., Cullis, C., Driscoll, D.L., Elder, A., Forsyth, N., Frazer, J., Guo, J., Guo, L., Hyer, M.L., Janowick, D., Kulkarni, B., Lai, S.J., Lasky, K., Li, G., Li, J., Liao, D., Little, J., Peng, B., Qian, M.G., Reynolds, D.J., Rezaei, M., Scott, M.P., Sells, T.B., Shinde, V., Shi, Q.J., Sintchak, M.D., Soucy, F., Sprott, K.T., Stroud, S.G., Nestor, M., Visiers, I., Weatherhead, G., Ye, Y., D'Amore, N. J.Med.Chem.